Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.3K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Accuracy of large language models in head and neck cancers: a comparative analysis of ChatGPT and Gemini in TNM staging and clinical decision support.

Frontiers in oncology·2026
Same author

Analysis of serum calprotectin levels in ménière's patients and investigation of its effect on disease severity.

PloS one·2026
Same author

Assessment of Raftlin and blood count parameters in otosclerosis.

Frontiers in neurology·2025
Same author

Postoperative Anatomical and Functional Success Rates of Pediatric Patients with Chronic Otitis Media: Our Experiences.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India·2023
Same author

Investigation of EGF, IL1-α and IL-6 levels and selected hematological parameters (NLR, MPV) in patients with the chronic cholesteatomatous otitis media.

Acta biochimica Polonica·2022
Same author

Evaluation of the vestibular system in individuals with presbycusis using video head impulse test and videonystagmography.

Acta oto-laryngologica·2021

Related Experiment Video

Updated: Apr 24, 2026

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

1.8K

Association between systemic inflammatory markers and otosclerosis: a retrospective case-control study.

Hüseyin Işık1, Deniz Baklaci1

  • 1Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Türkiye.

Frontiers in Neurology
|April 23, 2026
PubMed
Summary

Otosclerosis is linked to systemic inflammation, as indicated by a higher Systemic Immune-Inflammation Index (SII). This finding suggests a potential inflammatory component in otosclerosis, warranting further investigation in larger studies.

Keywords:
hearing-disordersinflammationneutrophil-to-lymphocyte ratiootosclerosissystemic immune-inflammation index

More Related Videos

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

19.7K
Synovial Fluid Analysis to Identify Osteoarthritis
07:51

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

7.7K

Related Experiment Videos

Last Updated: Apr 24, 2026

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology
03:42

High-Speed Human Temporal Bone Sectioning for the Assessment of COVID-19-Associated Middle Ear Pathology

Published on: May 18, 2022

1.8K
Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

19.7K
Synovial Fluid Analysis to Identify Osteoarthritis
07:51

Synovial Fluid Analysis to Identify Osteoarthritis

Published on: October 20, 2022

7.7K

Area of Science:

  • Otorhinolaryngology
  • Immunology
  • Hematology

Background:

  • Otosclerosis is a metabolic bone disease affecting the otic capsule, potentially involving inflammatory processes.
  • Systemic inflammatory markers like the Neutrophil-to-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) may reflect underlying inflammation in various conditions.

Purpose of the Study:

  • To investigate the association between otosclerosis and systemic inflammatory indices, specifically NLR and SII.
  • To determine if alterations in these inflammatory markers can serve as indicators for otosclerosis.

Main Methods:

  • A retrospective case-control study comparing 52 otosclerosis patients (stapedotomy) with 50 controls (septoplasty).
  • Analysis of preoperative complete blood counts to calculate NLR and SII.
  • Statistical analyses included group comparisons, multivariable logistic regression, and ROC curve analysis.

Main Results:

  • The Systemic Immune-Inflammation Index (SII) was significantly higher in the otosclerosis group compared to controls (p=0.041).
  • While the Neutrophil-to-Lymphocyte Ratio (NLR) was numerically higher in otosclerosis patients, it did not reach statistical significance (p=0.107).
  • Multivariable analysis confirmed SII as an independent factor associated with otosclerosis (OR=1.24, p=0.047), with moderate discrimination shown by ROC analysis (AUC=0.658).

Conclusions:

  • The Systemic Immune-Inflammation Index (SII) shows an independent association with otosclerosis, suggesting a subtle systemic immune-inflammatory signature.
  • These exploratory findings require validation in larger prospective studies due to borderline significance and moderate predictive performance.