Skin Organoids in Diabetic Chronic Wounds: Current Status and Future Perspectives

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Tissue Engineering

Background:

• Diabetes is a global health crisis with rising incidence, leading to severe complications like chronic wounds, particularly diabetic foot ulcers.
• Diabetic chronic wounds present significant challenges due to impaired healing, reduced quality of life, and substantial healthcare burdens.
• Conventional treatments for diabetic wounds are often insufficient, lacking adequate reparative capacity and functional tissue sources.

Purpose of the Study:

• To review the barriers in diabetic wound healing.
• To explore the regenerative mechanisms of skin organoids for tissue repair.
• To summarize recent advancements and future directions for applying skin organoids in diabetic chronic wound management.

Main Methods:

• This review synthesitsizes current literature on skin organoids and diabetic wound healing.
• It focuses on engineering strategies, regenerative potential, and translational considerations.
• Key challenges hindering clinical translation are analyzed.

Main Results:

• Skin organoids represent emerging biomimetic constructs with potential for diabetic ulcer repair.
• Engineering strategies are crucial for harnessing the regenerative capacity of organoids.
• Significant challenges remain, including model consistency, vascularization, and immune compatibility.

Conclusions:

• Skin organoids show promise for advancing diabetic chronic wound repair.
• Addressing challenges in model development and clinical translation is essential.
• This review provides a framework for future research towards clinical application of skin organoids.