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Updated: Apr 24, 2026

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[Nanomaterial-driven Lateral Flow Immunoassay: Technological Development and Application].

Jian Zheng1, Xuejiao Hu1, Bing Gu1

  • 1（） （ 510080）Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|April 23, 2026
PubMed
Summary
This summary is machine-generated.

Lateral flow immunoassays (LIFA) offer a user-friendly, cost-effective solution for point-of-care testing. Advancements in LIFA technology are paving the way for next-generation diagnostics and improved public health responses.

Keywords:
FluorescenceLateral flow immunoassayNanomaterialsPoint-of-care diagnostic toolRaman spectrumReview

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Area of Science:

  • Biomedical Engineering
  • Analytical Chemistry
  • Clinical Diagnostics

Background:

  • Traditional clinical testing relies on large, automated instruments.
  • Growing demand for point-of-care testing (POCT) necessitates portable, easy-to-use analytical reagents.
  • Lateral flow immunoassay (LIFA) technology has emerged as a key POCT solution due to its simplicity and speed.

Purpose of the Study:

  • To review the historical development of LIFA technology.
  • To highlight cutting-edge LIFA approaches and their potential.
  • To inspire future research and development in LIFA for diagnostics.

Main Methods:

  • Review of historical LIFA development.
  • Analysis of current advanced LIFA technologies.
  • Discussion of emerging LIFA applications in healthcare.

Main Results:

  • LIFA offers cost-effectiveness, ease of disposal, and rapid results.
  • Innovations include gold nanoparticle-based, magnetic, photothermal, fluorescent, and SERS LIFA.
  • LIFA is poised for integration into daily health management and emergency response.

Conclusions:

  • LIFA technology represents a significant advancement in diagnostic testing.
  • Future LIFA developments promise enhanced convenience and public health responsiveness.
  • Continued research will drive the evolution of LIFA for broader applications.