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Updated: Apr 24, 2026

Measurements of Physiological Stress Responses in C. Elegans
Published on: May 21, 2020
GPCR systems coordinate cellular resilience against aging-associated stress
Tabitha Boeringer1, Mia Pardo1, Carter J Craig1
1Receptor Biology Lab, Department of Drug Discovery, Moffitt Cancer Center, Tampa, FL, United States.
Abstract:
Aging-related diseases arise from cumulative cellular damage driven by diverse stressors. G protein-coupled receptors (GPCRs) play a critical role in coordinating cellular resilience to these stressors. We propose that stable multiprotein GPCR complexes-termed "receptorsomes"-function as adaptive hubs that sense, integrate, and mitigate stress across subcellular compartments. Receptorsomes comprise a GPCR core non-covalently associated with specific adaptors (e.g., β-arrestins, GIT2, RGS proteins, ASK1, YAP/TAZ), enabling pluridimensional, G protein-independent signaling that balances stress detection, damage repair, and homeostasis. This review synthesizes evidence linking receptosome composition to responses against oxidative, proteostatic, hypoxic, and other stressors, mapping these to aging hallmarks. We hypothesize that therapeutically tuning receptorsome adaptor engagement could enhance resilience, delay pathology, and extend health span, offering predictions for future testing.
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