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Potential Roles of G Protein-Coupled Receptor 30 (GPR30) in Migraine Pathophysiology

Yuning Yao1, Yang Gong1, Kegang Cao2

  • 1Department of Traditional Chinese Medicine, General Hospital of the PLA Northern Theater Command, Shenyang, Liaoning, People's Republic of China.

Journal of Pain Research
|April 23, 2026
PubMed

Insights

G protein-coupled receptor 30 (GPR30) plays a role in migraine pathogenesis, particularly in the trigeminal ganglion. Further research is needed to clarify its mechanisms and therapeutic potential for migraine treatment.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Molecular Biology

Background:

  • Migraine is a common neurological disorder with complex pathogenesis.
  • G protein-coupled receptor 30 (GPR30), initially viewed as a membrane estrogen receptor, is implicated in migraine pathophysiology.
  • GPR30 is notably expressed in the trigeminal ganglion, a key area in migraine.

Purpose of the Study:

  • To systematically review current research on GPR30's role in migraine pathogenesis.
  • To explore GPR30's molecular structure, ligands, distribution, and signaling pathways.
  • To assess GPR30's regulatory effects on migraine-associated neural functions.

Main Methods:

  • Systematic literature review of GPR30's involvement in neurological diseases, specifically migraine.
  • Analysis of studies on GPR30's molecular characteristics and distribution in the nervous system.
  • Evaluation of research on GPR30's impact on signal transduction pathways and neurovascular functions.

Main Results:

  • GPR30 influences migraine-related signal pathways and neural functions, but findings are sometimes contradictory.
  • Evidence linking GPR30 to estrogen-mediated regulation in migraine is inconclusive.
  • Clinical trials targeting GPR30 for migraine are lacking, and estrogen connections are not well-established.

Conclusions:

  • GPR30 presents a potential novel therapeutic target for migraine prevention and treatment.
  • Contradictory findings and lack of clinical data highlight challenges and future research directions.
  • Developing GPR30-targeted therapies requires further investigation into its precise mechanisms in migraine.
Keywords:
G protein-coupled estrogen receptorG protein-coupled receptor 30GPERGPR30migraine

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