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Immune Biomarkers in Fibromyalgia After a Qigong Programme: An Exploratory Randomized Controlled Study.

Juan M Manzaneque1, Francisca M Vera1, Francisco M Rodriguez-Peña2,3

  • 1Department of Psychobiology and Methodology of Behavioral Science University of Malaga Malaga Spain.

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|April 23, 2026
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Summary
This summary is machine-generated.

Qigong practice for one month significantly altered immune markers in fibromyalgia patients, affecting lymphocyte subsets and complement levels. Further research is needed to understand these immunomodulatory effects.

Keywords:
fibromyalgiaimmune biomarkersmind‐body therapiespsychosomaticqigong

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Area of Science:

  • Integrative and Complementary Medicine
  • Immunology
  • Rheumatology

Background:

  • Qigong, an ancient Chinese mind-body practice, offers holistic health benefits but is understudied in fibromyalgia.
  • While qigong's immune effects are researched, its impact on fibromyalgia immune parameters remains unexplored.

Purpose of the Study:

  • To investigate the effects of a qigong program on white blood cells and immune parameters in individuals with fibromyalgia.

Main Methods:

  • A 4-week qigong program was administered to an experimental group (16 participants).
  • A control group (23 participants) did not undergo qigong intervention.
  • Blood samples were analyzed pre- and post-intervention for immune parameters, including leukocyte counts, lymphocyte subsets, immunoglobulins, and complement levels.

Main Results:

  • The experimental group showed significant reductions in specific lymphocyte subsets (CD3, CD4, CD8, CD16, CD45) and total lymphocyte percentage.
  • A notable increase in CD19 percentage and C3 complement concentration was observed in the qigong group.

Conclusions:

  • One month of qigong practice induced significant changes in various immunological biomarkers in fibromyalgia patients.
  • Observed immunomodulation suggests potential benefits, but further research is required to elucidate the precise mechanisms and implications for fibromyalgia management.