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Published on: April 19, 2024

Current status of vaccine clinical trials registered on China's Drug Trial Registration and information disclosure

Sumei Zhong1,2, Zhiqiang Lin1, Junrong Li1

  • 1Fujian Provincial Center for Disease Control and Prevention, Fuzhou, Fujian, China.

Frontiers in Public Health
|April 23, 2026
PubMed
Abstract

Insights

China

Area of Science:

  • Clinical Research
  • Vaccinology
  • Public Health

Background:

  • Vaccines are crucial for preventing infectious diseases and addressing emerging health threats like COVID-19.
  • China's vaccine development is advancing due to public health needs and regulatory support.
  • Limited comprehensive analyses exist on vaccine clinical trials in China.

Purpose of the Study:

  • To systematically review vaccine clinical trials registered in China from 2013 to 2024.
  • To analyze trends in trial design, phase distribution, vaccine types, and geographic focus.
  • To provide insights into the evolving landscape of vaccine research in China.

Main Methods:

  • Data sourced from the Drug Trial Registration and Information Publication Platform.
  • Included 620 eligible vaccine clinical trials after deduplication and exclusion.
  • Analyzed trial design, phase, participant demographics, vaccine type, and institutional affiliations.

Main Results:

  • Most trials were parallel-group (84.84%), randomized (81.94%), and double-blind (67.58%).
  • Phase I (30.27%) and Phase III (35.75%) trials were most common.
  • Influenza (17.1%), HPV (13.4%), and pneumococcal (9.8%) vaccines were frequently studied; trials concentrated in eastern provinces.

Conclusions:

  • China shows consistent growth in vaccine clinical trial activity.
  • Opportunities exist to enhance multi-center collaboration and trial diversity.
  • Findings support evidence-based policy for China's vaccine development.
Keywords:
Chinaclinical trialsepidemiologypublic healthregulatory trendsvaccine

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