Cerebral in situ ischemic postconditioning: From bench to bedside and beyond

Area of Science:

• Neurology
• Cardiovascular Research
• Interventional Neurology

Background:

• Ischemic postconditioning (IPostC) is a therapeutic strategy to reduce ischemia-reperfusion injury.
• Its neuroprotective role after thrombectomy in acute ischemic stroke (AIS) requires further clinical investigation.
• Existing research primarily focuses on non-neurological organs.

Purpose of the Study:

• To evaluate the feasibility, clinical relevance, and safety of IPostC in AIS patients.
• To assess the translational success of IPostC from preclinical to clinical settings.
• To propose an optimized IPostC protocol for stroke treatment.

Main Methods:

• Review of preclinical data on IPostC in non-neurological organs.
• Analysis of animal models of cerebral ischemia (rodents, canines).
• Synthesis of findings from related endovascular interventions.

Main Results:

• IPostC shows translational success in non-neurological organs.
• Animal models suggest potential neuroprotective benefits of IPostC in cerebral ischemia.
• Clinical translation of IPostC for stroke is deemed feasible and potentially beneficial.

Conclusions:

• IPostC is a feasible and potentially beneficial strategy for AIS patients.
• An optimized IPostC protocol can enhance safety and efficacy.
• A novel in situ neurointerventional IPostC technique is proposed for clinical application.