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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Ketoacidosis in new-onset type 1 diabetes: return to pre-COVID-19 pandemic reality?

Rita Gomes Alvelos1,2, Paula Santos2,3, Mariana Sebastião2

  • 1Department of Paediatrics, Unidade Local de Saúde Região de Aveiro, Portugal. 72169@chbv.min-saude.pt.

Pediatric Endocrinology, Diabetes, and Metabolism
|April 23, 2026
PubMed

Insights

Type 1 diabetes (T1D) severity increased during the COVID-19 pandemic. While post-pandemic presentation improved, continued focus on preventing diabetic ketoacidosis in children with T1D is crucial.

Area of Science:

  • Pediatric Endocrinology
  • Infectious Disease Epidemiology

Background:

  • Type 1 diabetes mellitus (T1D) is a growing global health concern in childhood.
  • The COVID-19 pandemic has been linked to more severe diabetic ketoacidosis cases.

Purpose of the Study:

  • To analyze the impact of the COVID-19 pandemic on the severity of diabetic ketoacidosis in children with T1D.
  • To compare T1D presentation and severity across pre-pandemic, pandemic, and post-pandemic periods.

Main Methods:

  • A retrospective cohort study analyzed clinical records from March 2016 to March 2024.
  • Patient data was categorized into three groups: pre-pandemic (2016-2020), pandemic (2020-2021), and post-pandemic (2021-2024).

Main Results:

  • The study observed a trend towards improved presentation severity in the post-pandemic phase.
  • Despite improvements, the incidence of ketoacidosis remained elevated.

Conclusions:

  • Post-pandemic data suggests a reduction in T1D severity at initial presentation.
  • Sustained high rates of ketoacidosis underscore the need for enhanced preventative strategies in pediatric T1D management.
Abstract

Keywords:
COVID-19.diabetic ketoacidosisdiabetes mellitus type 1

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