Neuroectodermal interleukin 12 signaling attenuates spinal cord inflammation and demyelination
Arshad Mehmood1, Miraj Din1, Muhammad Munawer1
1State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Introduction:
Interleukin 12 (IL-12) is a driver of type 1 immunity. Interleukin 12 reduces inflammation in an autoimmune condition in the spinal cord. The aim of this study was to investigate the therapeutic effect of IL-12 in the experimental autoimmune encephalomyelitis model.
Material And Methods:
Interleukin 12 expression was mapped in neurons, oligodendrocytes, natural killer cells, and T lymphocyte cells in the spinal cord of experimental autoimmune encephalomyelitis mice.
Results:
Interleukin 12 ablation in neurons, oligodendrocytes, natural killer, and T lymphocyte cells in mice and their susceptibility to experimental autoimmune encephalomyelitis showed that the neuroprotective role of IL-12 is mediated by neuroectoderm-derived cells - neurons.
Conclusions:
Single-nucleus RNA sequencing revealed an IL-12 receptor-induced neuroprotective effect that prevents neurodegeneration, sustains trophic factor release in neuroinflammation, and maintains spinal cord integrity.
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