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Paediatric Central Venous Access Devices: An Evidence and Gap Map of Global Research

Tricia M Kleidon1,2,3, Sabrina de Souza2, Patrícia Kuerten Rocha4

  • 1Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, South Brisbane, Queensland, Australia.

Journal of Paediatrics and Child Health
|April 23, 2026
PubMed

Insights

This study maps evidence on pediatric central venous access device (CVAD) interventions, revealing significant gaps in research. Future studies should focus on rigorous, diverse, and outcome-specific pediatric CVAD research.

Area of Science:

  • Pediatric healthcare research
  • Evidence synthesis and mapping
  • Medical device interventions

Background:

  • Central venous access devices (CVADs) are critical in pediatric care but carry substantial risks.
  • There is a need to synthesize evidence for safe, effective, and equitable CVAD practice.
  • Evolving interventions and complex management require updated evidence.

Purpose of the Study:

  • To create an evidence and gap map (EGM) of pediatric research on interventions improving CVAD outcomes.
  • To identify, categorize, and visualize existing evidence.
  • To highlight areas needing further investigation.

Main Methods:

  • Systematic searches conducted in major databases (PubMed, CINAHL, Scopus, CENTRAL) from 2014 to June 2024.
  • Included randomized and non-randomized trials, implementation studies, and systematic reviews for patients aged 0-18 years.
  • Data extraction by two independent reviewers, descriptive analysis, and visualization using Tableau.

Main Results:

  • 151 pediatric-specific studies identified from 952 broader EGM studies.
  • Most studies originated from high-income countries (72%), focusing on critical care (41.9%) and oncology (38.5%).
  • Evidence primarily covers infection prevention and insertion technologies, with limited reporting on patient-reported or economic outcomes.

Conclusions:

  • Significant evidence gaps exist for pediatric CVAD interventions.
  • The majority of studies lacked control groups or detailed CVAD type information.
  • Future research must prioritize rigorous, pediatric-specific studies across diverse settings and outcome measures.
Abstract

Keywords:
catheterisationcentral venousevidence‐based nursingpaediatricssystematic reviewvascular access devices

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