Selenium-Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers

Area of Science:

• Oncology
• Nanotechnology
• Trace Element Research

Background:

• Gynecological cancers pose significant treatment challenges due to heterogeneity and drug resistance.
• Epidemiological studies link lower selenium levels to increased gynecological cancer risk and poorer prognosis.
• Selenium's potential as a biomarker, chemopreventive agent, and therapeutic adjuvant in oncology is recognized.

Purpose of the Study:

• To review advances in using various selenium species for gynecological cancer treatment.
• To highlight the therapeutic mechanisms and applications of selenium-based nanoparticles in cancer diagnosis and imaging.
• To explore the potential of selenium-based nanoparticles for early diagnosis and treatment of gynecological cancers.

Main Methods:

• Systematic review of existing literature on selenium species in gynecological cancer therapy.
• Analysis of studies focusing on inorganic, organic, and selenium-based nanoparticles.
• Evaluation of research on therapeutic mechanisms, bioavailability, toxicity, and diagnostic applications.

Main Results:

• Selenium-based nanoparticles demonstrate superior bioavailability, anticancer activity, and reduced toxicity compared to other forms.
• Selenium-based nanoparticles exhibit multifaceted therapeutic mechanisms relevant to gynecological cancers.
• These nanoparticles show potential for integrated cancer diagnosis and imaging.

Conclusions:

• Selenium-based nanoparticles represent a promising therapeutic strategy for gynecological cancers.
• Their unique properties offer new avenues for early diagnosis and targeted treatment.
• Further research into selenium-based nanoparticles can provide novel insights for gynecological cancer management.