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Interfacial Hydrogen Bond-Mediated Rigidification Strategy Coupled with Stepwise Antenna Effect for Ultrasensitive
Ziyu Zhao1, Xueling Shan1, Yuqi Wu1
1Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, P. R. China.
Analytical Chemistry
|April 23, 2026
Summary
This study introduces a novel electrochemiluminescence (ECL) sensor using lanthanide metal-organic frameworks (Ln-MOFs) integrated with conductive aluminum-based metal-organic gel (AlOG). The new design enhances sensitivity for detecting zearalenone, a mycotoxin.
Area of Science:
- Materials Science
- Analytical Chemistry
- Nanotechnology
Background:
- Lanthanide metal-organic frameworks (Ln-MOFs) show promise as electrochemiluminescence (ECL) emitters due to the lanthanide antenna effect.
- However, ligand vibrations and poor MOF conductivity limit ECL sensor performance.
Purpose of the Study:
- To develop a high-performance ECL sensor by addressing limitations in Ln-MOF based systems.
- To create a sensitive biosensing platform for zearalenone detection.
Main Methods:
- Integration of aluminum-based metal-organic gel (AlOG) with europium/terbium metal-organic framework nanorods (Eu/Tb-MOF NRs).
- Construction of an ordered hydrogen-bonding network at the composite interface.
- Utilizing a conductive matrix and radical-mediated stepwise antenna effect for enhanced ECL.
Main Results:
- The composite structure suppressed ligand vibrations and improved charge injection via the AlOG 'electron highway'.
- A stepwise antenna effect involving Ln-MOFs and AlOG ligands enhanced ECL signals.
- The sensor achieved a low detection limit (6.615 × 10⁻¹⁶ M) for zearalenone with a wide linear range and excellent selectivity.
Conclusions:
- The developed sensor offers a reliable platform for rapid mycotoxin monitoring.
- This work presents a novel design strategy for high-performance Ln-MOF-based ECL systems through interfacial engineering and conductive matrices.
