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Frailty in Rheumatoid Arthritis: Associations With Performance Tests, Psychological Resilience, and the Geriatric 8

Bulent Akyuz1, Oyku Tomay Aksoy2, Gizem Basak2

  • 1Department of Rheumatology, Akdeniz University Hospital, Antalya.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|April 23, 2026
PubMed
Summary

Adults with rheumatoid arthritis (RA) demonstrate poorer physical function and G8 screening results compared to controls. Disease activity and resilience significantly impact these outcomes in RA patients.

Keywords:
frailtygeriatric 8 screenpsychological resiliencerheumatoid arthritistimed up and go test

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Area of Science:

  • Rheumatology
  • Gerontology
  • Physical Performance Measurement

Background:

  • Rheumatoid arthritis (RA) is a systemic autoimmune disease impacting joints and potentially leading to frailty.
  • Frailty assessment in RA is crucial for understanding disease impact beyond joint symptoms.

Purpose of the Study:

  • To compare frailty-related performance and G8 screening results between adults with RA and matched controls.
  • To examine the associations of disease activity (DAS28-CRP) and resilience with these outcomes in RA.

Main Methods:

  • Cross-sectional study of 100 adults with RA and 100 age/sex-matched controls.
  • Assessed timed up and go (TUG), 4-m gait speed, and G8 screening tool.
  • Multivariable models analyzed continuous outcomes and predefined thresholds in the RA group.

Main Results:

  • RA patients exhibited significantly longer TUG times, slower gait speed, and lower G8 scores compared to controls (p≤0.026).
  • Higher DAS28-CRP in RA was associated with poorer TUG, gait speed, and G8 scores.
  • Increased resilience in RA was linked to better TUG, gait speed, and G8 scores.

Conclusions:

  • Adults with RA present with less favorable physical performance and G8 screening profiles than matched controls.
  • Disease activity and resilience are independently associated with objective performance and G8 outcomes in RA.
  • Further longitudinal research is required to establish temporal relationships and prognostic significance.