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Hybrid MXene/Hydrogel Integration with Modulated Bioactivities for Synergistic Diabetic Wound Therapy
Ligang Zou1, Yuanyuan Liu2, Jiaqi Liu1
1College of Biomedical Engineering, Chongqing Medical University, Chongqing 400016, P. R. China.
Nano Letters
|April 23, 2026
Summary
This study introduces a self-healing hydrogel for diabetic wounds, combining photothermal therapy, antioxidant action, and growth factor release. The innovative material significantly accelerates wound healing and reduces inflammation.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Nanotechnology
Background:
- Diabetic wound management is challenging due to infection, oxidative stress, and poor angiogenesis.
- Current treatments often lack multi-faceted approaches to address these complex issues simultaneously.
Purpose of the Study:
- To develop a dynamic, self-healing hydrogel platform for effective diabetic wound treatment.
- To integrate Ti3C2 MXene nanosheets and epidermal growth factor (EGF) for synergistic therapeutic effects.
Main Methods:
- Fabrication of a glutathione-modified chitosan/alginate hydrogel with dynamic Schiff-base cross-linking.
- Incorporation of Ti3C2 MXene nanosheets for photothermal antibacterial activity and on-demand EGF release.
- In vivo evaluation in a diabetic wound model.
Main Results:
- The hydrogel demonstrated excellent tissue adhesion and conformability.
- Near-infrared irradiation triggered photothermal antibacterial effects and EGF release, promoting neovascularization.
- In vivo studies showed 96% wound closure, reduced inflammation, and restored tissue architecture.
Conclusions:
- The developed MXene-based hydrogel offers a triple-synergistic strategy for diabetic wound healing.
- This platform shows significant potential for treating inflammation-associated pathologies.
- The study highlights the promise of rationally engineered hydrogels in regenerative medicine.
