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Published on: February 3, 2015
Total body PET for radiopharmaceutical discovery
1Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Research, Investigation and Evaluation of Radiopharmaceuticals, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, 52nd Fucheng Road, 100142, Beijing, China.
Total body PET imaging enhances radiopharmaceutical clinical evaluation by enabling precise pharmacokinetic and dosimetric assessments. This advanced molecular imaging accelerates drug development by bridging preclinical and human studies.
Area of Science:
- Molecular imaging
- Radiopharmaceutical development
- Clinical evaluation
Background:
- Positron Emission Tomography (PET) is crucial for evaluating radiopharmaceuticals in drug development.
- Traditional PET has limitations in comprehensive whole-body assessment.
Purpose of the Study:
- To review the transformative impact of total body PET on radiopharmaceutical clinical evaluation.
- To highlight how total body PET accelerates drug development pipelines.
Main Methods:
- Review of total body PET capabilities and applications.
- Discussion of enhanced sensitivity and extended field of view.
- Focus on quantitative accuracy for compound comparison.
Main Results:
- Total body PET enables comprehensive, whole-body dynamic imaging.
- Facilitates precise pharmacokinetic and dosimetric assessments in early trials.
- Allows nuanced comparison of similar drug candidates based on in vivo behavior.
Conclusions:
- Total body PET represents a major technological advancement in molecular imaging.
- It effectively bridges the gap between preclinical research and clinical application.
- Accelerates the clinical evaluation and development of novel radiopharmaceuticals.
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