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Assessment of oxidative and inflammatory biomarkers in denture-related traumatic ulcers treated with different
Nemanja Okicic1, Andjela Milojevic Samanovic2, Milica Jovanovic3
1Department of Dental Prosthetics, Military Medical Academy, 17 Crnotravska St., Belgrade 11000, Serbia.
Objective:
To investigate the potential role of oxidative and inflammatory status in saliva during the healing of denture-related traumatic ulcers, applying various topical agents.
Design:
The prospective cohort study included 100 participants with denture-related traumatic ulcers, divided into five groups: traumatic ulcers that were not treated and treated with topical agents (0.2% hyaluronic acid gel, 0.3% hyaluronic acid-taurine gel, a gel based on an herbal preparation, and panthenol mouthwash) for seven days. Unstimulated saliva samples were collected. Oxidative stress parameters were determined spectrophotometrically. Inflammatory markers and vascular endothelial growth factor (VEGF) were analyzed using an enzyme-linked immunosorbent assay. Data were analysed by Kruskal-Wallis and Mann-Whitney U test (P < 0.05).
Results:
The values of superoxide anion radical, index of lipid peroxidation, and hydrogen peroxide were significantly decreased in groups that used gels based on hyaluronic acid or hyaluronic acid-taurine compared to other groups (P < 0.05); conversely, superoxide dismutase, catalase, and reduced glutathione were significantly increased (P < 0.05). The levels of interleukin-6, interleukin-17, and tumor necrosis factor alpha were significantly decreased (P < 0.05), while the levels of interleukin-10 and VEGF were significantly increased in the hyaluronic acid or hyaluronic acid-taurine groups in comparison to other treatments (P < 0.05).
Conclusion:
Hyaluronic acid or hyaluronic acid-taurine gels were associated with pronounced changes in salivary biomarkers, reflecting improvements in redox status, inflammation balance, and angiogenesis. The current research may help clarify the potential molecular mechanisms influencing the healing of traumatic ulcers after the placement of new removable dentures using various topical agents, with due consideration of study limitations.
