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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K
Notch Signaling Pathway03:14

Notch Signaling Pathway

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4.9K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
1.8K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
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NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

7.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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Related Experiment Video

Updated: Apr 25, 2026

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Notch Signalling Pathway in the Pathogenesis of Periodontitis: Research Progress.

Cheng Shang1, Churen Zhang2, Jianxia Hou1

  • 1Department of Periodontology, Peking University School and Hospital of Stomatology and National Centre of Stomatology and National Clinical Research Centre for Oral Diseases and National Engineering Laboratory for Digital and Material Technology of Stomatology and Beijing Key Laboratory of Digital Stomatology and Research Centre of Engineering and Technology for Computerised Dentistry Ministry of Health and NMPA Key Laboratory for Dental Materials, Beijing, China.

International Dental Journal
|April 23, 2026
PubMed
Summary
This summary is machine-generated.

The Notch signalling pathway plays a key role in periodontitis, affecting inflammation and bone loss. Understanding this pathway offers potential new treatments for this gum disease.

Keywords:
Cell signallingInflammatory responseNotch signalling pathwayPathogenesisPeriodontitis

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Area of Science:

  • Oral biology
  • Immunology
  • Molecular biology

Background:

  • Periodontitis is a complex inflammatory disease affecting the gums and supporting bone.
  • The Notch signalling pathway is crucial for cell communication and tissue development.
  • Dysregulation of Notch signalling is implicated in various inflammatory and degenerative conditions.

Purpose of the Study:

  • To review the role of the Notch signalling pathway in periodontitis pathogenesis.
  • To explore Notch signalling's impact on host inflammatory responses, immune regulation, and alveolar bone homeostasis.
  • To identify the Notch signalling pathway as a potential therapeutic target for periodontitis.

Main Methods:

  • Comprehensive literature review of recent advances in Notch signalling and periodontitis research.
  • Analysis of mechanistic insights, experimental findings, and clinical evidence.
  • Critical examination of current knowledge on Notch signalling in periodontal disease.

Main Results:

  • The Notch signalling pathway significantly influences periodontitis pathogenesis.
  • Evidence demonstrates the pathway's involvement in inflammation, immune response, and tissue regeneration.
  • The pathway is implicated in disease progression and presents potential as a therapeutic target.

Conclusions:

  • Notch signalling is critical in periodontitis, deepening understanding of disease mechanisms.
  • Further research is needed to develop novel therapeutic strategies targeting Notch signalling.
  • Translating research findings into clinical applications for periodontitis treatment is essential.