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Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.4K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Apr 25, 2026

A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft
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A Murine Model of a Burn Wound Reconstructed with an Allogeneic Skin Graft

Published on: August 8, 2020

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Advances in stem cell-based tissue-engineered skin substitutes for burns.

Faraz Chogan1, Yufei Chen2, Eshaan Maneyapanda3

  • 1Institute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Centre for Burn Research, Hamilton Health Sciences, Hamilton, Ontario, Canada.

Trends in Biotechnology
|April 23, 2026
PubMed
Summary

This review explores stem cell-based skin substitutes for burn care, detailing innovative biofabrication methods like 3D bioprinting and hydrogels to overcome limitations of traditional skin grafts.

Keywords:
3D bioprintingbioengineered skin substitutesburnsclinical translationstem cellstissue engineering

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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
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Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding
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Area of Science:

  • Regenerative Medicine and Biomedical Engineering
  • Tissue Engineering for Dermatological Applications

Background:

  • Burn injuries result in significant morbidity, mortality, and long-term functional and aesthetic impairments.
  • Autologous skin grafting, while effective, faces limitations due to donor site availability and potential for scarring and contracture.
  • There is a critical need for advanced skin substitutes that can better restore native skin function after burns.

Purpose of the Study:

  • To review recent innovations in stem cell-based tissue-engineered skin substitutes for burn care.
  • To highlight various biofabrication platforms utilized in creating these advanced skin substitutes.
  • To discuss challenges and opportunities for clinical translation of these technologies in burn treatment.

Main Methods:

  • Review of recent scientific literature on stem cell-based skin substitutes for burn applications.
  • Identification and categorization of various biofabrication platforms, including 3D bioprinting, hydrogels, electrospinning, and stem cell sheets.
  • Analysis of challenges and opportunities for clinical implementation in burn management.

Main Results:

  • Stem cell-based skin substitutes show promise for improved burn wound coverage and function.
  • Diverse biofabrication techniques, such as 3D bioprinting, spray-on systems, and stem cell sheets, are advancing the field.
  • Despite innovations, clinical application in burn care is still limited, indicating a need for further development.

Conclusions:

  • Stem cell-based tissue engineering offers promising alternatives to autologous grafting for burn injuries.
  • Advancements in biofabrication platforms are crucial for developing effective and functional skin substitutes.
  • Addressing key challenges is essential for successful clinical translation and widespread adoption in burn care.