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Updated: Apr 25, 2026

Author Spotlight: Accelerating Research on Bacterial Extracellular Vesicles Separation and Heterogeneity
Published on: September 1, 2023
Curcumin-loaded extracellular vesicles derived from lactic acid bacteria for alleviation of inflammatory bowel
Fang Qiu1, Baixuan Wang1, Yongjing Zhang1
1College of Food Science and Engineering, Shandong Agricultural University, Taian 271018, China; Key Laboratory of Food Nutrition and Human Health in Universities of Shandong, Shandong Agricultural University, Taian 271018, China.
Abstract:
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by symptoms such as diarrhea, bleeding, and an elevated risk of colorectal cancer. Bacterial extracellular vesicles (EVs) have emerged as a promising delivery system for bioactive compounds, owing to their high biocompatibility, low immunogenicity, and cost-effectiveness. In this study, EVs were isolated from two Lactic acid bacteria (LAB)-Lactobacillus delbrueckii ssp. Bulgaricus and Streptococcus thermophilus, and curcumin was successfully encapsulated into these vesicles. Compared with those derived from S. thermophilus, the curcumin-loaded EVs from L. bulgaricus (L-EVs-C) demonstrated superior characteristics, including optimized particle size, higher encapsulation efficiency, enhanced antioxidant capacity, and improved gastrointestinal stability. In a DSS-induced colitis mouse model, L-EVs-C treatment significantly alleviated disease symptoms, and positively modulated the gut microbiota and enriching beneficial bacteria. These results underscore the potential of natural probiotics EVs as effective nanocarriers for bioactive compounds in the development of functional foods and therapeutic strategies.
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