Polyhexamethylene guanidine phosphate exposure induces abnormal behaviors by disrupting synaptic formation and
Moon Yi Ko1,2, Jiwon Choi3, Euijun Min1,4
1Center for Convergence Toxicology Research, Division of Next Generation Non-Clinical Research, Korea Institute of Toxicology, Daejeon, 34114, Republic of Korea.
Journal of Neuroinflammation
|April 23, 2026
Abstract
No abstract available in PubMed .
Related Concept Videos
Desensitization and Tachyphylaxis
3.4K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.4K
Hepatic Encephalopathy
26
DefinitionHepatic encephalopathy is a reversible neurologic syndrome that results from advanced liver dysfunction or portosystemic shunting. It leads to disturbances in cognition, behavior, and motor function due to the brain’s exposure to gut-derived toxins that the liver fails to detoxify.EtiologyThis condition develops either in the setting of acute fulminant hepatitis or progressively during chronic liver disease, such as cirrhosis and portal hypertension. Portosystemic...
26


