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Related Concept Videos

Applications Of NMR In Biology01:25

Applications Of NMR In Biology

3.3K
Nuclear magnetic resonance (NMR) spectroscopy is a very valuable analytical technique for researchers. It has been used for more than 50 years as an analytical tool. F. Bloch and E. Purcell formulated NMR in 1946 and won the 1952 Nobel Prize in Physics  for their work. Biological macromolecules such as proteins, nucleic acids, lipids, and organic molecules including pharmaceutical compounds, can be studied using this versatile tool that exploits the magnetic properties of certain nuclei.
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NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

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NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
2.0K
Nuclear Magnetic Resonance (NMR): Overview01:07

Nuclear Magnetic Resonance (NMR): Overview

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Nuclear magnetic resonance (NMR) is a phenomenon exhibited by certain nuclei that can absorb characteristic radio frequency radiation under certain conditions. NMR has been extensively applied in molecular spectroscopy and medical diagnostic imaging. In both these applications, the molecule or subject under study is placed in a magnetic field and irradiated with radio frequency energy.
NMR spectroscopy generates a spectrum where the characteristic absorption frequencies of the sample are...
6.8K
NMR Spectroscopy and Mass Spectrometry of Aldehydes and Ketones01:15

NMR Spectroscopy and Mass Spectrometry of Aldehydes and Ketones

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In aldehydes, the hydrogen atom connected to the carbonyl carbon helps distinguish aldehydes from other carbonyl compounds using ¹H NMR spectroscopy. The closeness of aldehydic hydrogen to the electrophilic carbonyl carbon highly deshields the hydrogen atom causing its signal to appear around 10 ppm in the ¹H NMR spectra. α hydrogens split the aldehydic proton signal, which helps identify the number of α hydrogens in the molecule. For instance, one α hydrogen creates a...
4.3K
¹H NMR Signal Integration: Overview00:58

¹H NMR Signal Integration: Overview

4.0K
The intensity of a signal, which can be represented by the area under the peak, depends on the number of protons contributing to that signal. The area under each peak is shown as a vertical line called an integral, with the integral value listed under it, as seen in the proton NMR spectrum of benzyl acetate. Each integral value is divided by the smallest integral value to obtain the ratio of the number of protons producing each signal. The ratio reveals the relative number of protons and not...
4.0K
2D NMR: Overview of Heteronuclear Correlation Techniques01:18

2D NMR: Overview of Heteronuclear Correlation Techniques

898
Heteronuclear correlation spectroscopy is an analytical technique that investigates the coupling between different types of nuclei, often a proton and an X-nucleus, such as carbon-13 or nitrogen-15. This method is commonly used in nuclear magnetic resonance (NMR) spectroscopy to gain insights into complex chemical compounds' structural and compositional aspects. A typical heteronuclear correlation spectrum displays X-nucleus chemical shifts on one axis and a proton spectrum on the other...
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Related Experiment Video

Updated: Apr 25, 2026

Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
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Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics

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Recent Trends in Metabolomics by NMR Spectroscopy.

Giorgio Di Paco1, Gaia Meoni1, Veronica Ghini1

  • 1Department of Chemistry, "Ugo Schiff", University of Florence, Via della Lastruccia, Sesto Fiorentino, Florence, Italy.

Angewandte Chemie (International Ed. in English)
|April 24, 2026
PubMed
Summary
This summary is machine-generated.

NMR-based metabolomics research has significantly advanced, with human health applications dominating the field. This review analyzes key findings and trends from 5081 studies published between 2018 and 2025.

Keywords:
NMR spectroscopyliterature analysismetabolomicsresearch trends

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Area of Science:

  • Metabolomics
  • Analytical Chemistry
  • Biochemistry

Background:

  • NMR-based metabolomics is a rapidly evolving field.
  • Previous reviews have highlighted key developments.
  • Continuous updates are necessary to track scientific production.

Purpose of the Study:

  • To critically analyze scientific production in NMR-based metabolomics from January 2018 to April 2025.
  • To identify key findings and trends across various application fields.
  • To provide an updated overview following the 2019 review.

Main Methods:

  • Systematic literature analysis strategy developed and applied.
  • Identification of 5081 relevant studies within the specified period.
  • Descriptive statistics used to summarize experimental parameters and application fields.

Main Results:

  • Six main fields of application identified: human health, food and nutrition, veterinary, plants, environment, and analytical methods.
  • Human health is the predominant application area, exceeding the combined share of other fields.
  • Analysis focused on highly cited articles within key topics in each field.

Conclusions:

  • NMR-based metabolomics continues to expand, with significant contributions to human health research.
  • The field demonstrates diverse applications, highlighting its versatility.
  • This review provides a comprehensive overview of recent advancements and identifies impactful research.