Electronic Structure-Engineered Vanadium Carbide MXene Nanocatalyst Enables Multimodal Reactive Species Scavenging...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Stem Cell Biology

Background:

• Efficient regulation of reactive oxygen and nitrogen species (ROS/RNS) is crucial for stem cell function in therapies.
• Current methods face challenges in effectively managing redox homeostasis in stem cell applications.

Purpose of the Study:

• To develop an advanced nanocatalyst for broad-spectrum ROS/RNS scavenging.
• To enhance stem cell protection and functionality under oxidative stress.

Main Methods:

• Engineered platinum nanoparticles on vanadium carbide (Pt/V2C) MXene.
• Investigated Pt/V2C interfacial interactions and electronic modulation.
• Assessed catalytic kinetics, stability, and enzyme-mimetic activities.
• Evaluated nanocatalyst efficacy in protecting mesenchymal stem cells (MSCs) against oxidative damage.

Main Results:

• Pt/V2C demonstrated enhanced catalytic kinetics for ROS/RNS scavenging.
• The nanocatalyst exhibited high stability and no cytotoxicity.
• Pt/V2C protected MSCs by reducing oxidative damage and restoring cell functions (adhesion, proliferation, migration).
• Promoted osteogenic differentiation of MSCs.

Conclusions:

• Pt/V2C serves as a high-performance biocatalyst for redox microenvironment regulation.
• This strategy offers a promising platform for stem cell protection in regenerative medicine.
• Electronic-structure engineering of MXene biocatalysts is a viable approach for therapeutic applications.