Related Experiment Video
Updated: Apr 25, 2026
Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
TFEB Activator Curcumin Analog C1 Downregulates PKM2 and Alleviates Inflammatory Injury in Endotoxemic Mice
Yanliuying Zhu1, Xinyan Zan2, Kerui Fan3
1Department of Pathophysiology, Basic Medical College, Xinjiang Second Medical College, Karamay, China.
Objective:
Autophagy dysfunction results in the accumulation of pro-inflammatory components and drives inflammatory injury. Transcription factor EB (TFEB) is a master regulator of autophagy and a novel target for controlling inflammatory injury. Curcumin analog C1 directly binds to and activates TFEB, but its anti-inflammatory effects remain unclear.
Methods:
The anti-inflammatory and protective effects of curcumin analog C1 were investigated in lipopolysaccharide (LPS)-induced endotoxemia mice.
Results:
Curcumin analog C1 reversed LPS-induced autophagy dysfunction, downregulated pyruvate kinase M2 (PKM2), and reduced pro-inflammatory cytokines including TNF-α, IL-6, and MCP-1. It also attenuated systemic abnormalities, alleviated lung injury, and decreased blood urea nitrogen (BUN), brain-type natriuretic peptide (BNP), and extracellular DNA levels.
Conclusions:
Curcumin analog C1 exhibits potential pharmacological value in the control of inflammatory injury.Thank you for your assistance.
