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ALK-Positive Lung Adenocarcinoma With Suspected Transformation to Squamous Cell Carcinoma in Lymph Node Metastases

Yusuke Okamoto1, Naofumi Miyahara1, Keita Kai2

  • 1Department of General Thoracic and Cardiovascular Surgery, Faculty of Medicine, University of Saga, Saga, Japan.

Annals of Thoracic Surgery Short Reports
|April 24, 2026
PubMed

Insights

Resistance to anaplastic lymphoma kinase (ALK) inhibitors is common in non-small cell lung cancer. This case shows a rare transformation to ALK-rearranged squamous cell carcinoma without prior ALK inhibitor exposure.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • Anaplastic lymphoma kinase (ALK) inhibitors are crucial in treating ALK-positive non-small cell lung cancer.
  • Mechanisms of resistance to ALK inhibitors are well-documented.
  • Histologic transformation is a known, albeit less common, resistance mechanism.

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