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Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Related Experiment Video

Updated: Apr 25, 2026

Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
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Concomitant Cryoablation for Atrial Fibrillation: FREEZE-AFIB Post-Market Study.

Evelio Rodriguez1, Arnar Geirsson2, Sabet Hashim3

  • 1Division of Cardiac Surgery, Department of Cardiac Sciences, Ascension Saint Thomas West Hospital, Nashville, Tennessee.

Annals of Thoracic Surgery Short Reports
|April 24, 2026
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Summary
This summary is machine-generated.

Cryothermal surgical ablation using the cryoICE cryoFORM device demonstrated high safety and effectiveness for treating atrial fibrillation. The study found 89% of patients were free from arrhythmias after 12 months.

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Area of Science:

  • Cardiovascular Surgery
  • Electrophysiology
  • Medical Devices

Background:

  • Surgical ablation is the established gold standard for treating atrial fibrillation.
  • Cryothermal-only surgical ablation is increasingly utilized, with growing evidence supporting its outcomes.

Purpose of the Study:

  • To evaluate the safety and performance of the cryoICE cryoFORM cryoablation probe in patients with nonparoxysmal atrial fibrillation.
  • To assess freedom from atrial arrhythmias and serious adverse events (SAEs) at 12-month follow-up.

Main Methods:

  • A post-market, multicenter, retrospective-prospective study (FREEZE-AFIB) involving patients undergoing concomitant Cox-Maze III lesions with the cryoICE cryoFORM device.
  • Primary endpoints included freedom from atrial arrhythmias (>30 seconds) and freedom from procedure-related SAEs within 30 days and 12 months.

Main Results:

  • The study included 33 patients (mean age 68.7 years, 76% male, 94% White).
  • Primary safety was achieved with 100% freedom from SAEs within 30 days and 97% freedom from SAEs and permanent pacemaker implantation through 12 months.
  • Primary performance was met, with 89% of patients free from atrial arrhythmias at 12 months off antiarrhythmic drugs.

Conclusions:

  • Cryothermal-only surgical ablation using the cryoICE cryoFORM device is safe and effective for treating nonparoxysmal atrial fibrillation.
  • The device demonstrated a favorable safety profile with a low rate of serious adverse events.
  • A significant majority of patients achieved freedom from atrial arrhythmias, supporting its clinical utility.