Related Experiment Video
Updated: Apr 25, 2026

Dynamic Adhesion Assay for the Functional Analysis of Anti-adhesion Therapies in Inflammatory Bowel Disease
Published on: September 20, 2018
Predicting Clinical Response to Granulocyte/Monocyte Adsorption Apheresis in Treatment-Resistant Ulcerative Colitis
Shintaro Yano1, Taro Osada1, Shingo Ogiwara1
1Department of Gastroenterology, Juntendo University Urayasu Hospital, Chiba, Japan.
Granulocyte/monocyte adsorption apheresis (GMA) shows promise for ulcerative colitis (UC). Decreased matrix metalloproteinase-9 (MMP-9) levels effectively predict patient response to GMA therapy.
Area of Science:
- Gastroenterology
- Immunology
- Biomarker Discovery
Background:
- Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
- Granulocyte/monocyte adsorption apheresis (GMA) is an adjuvant therapy for treatment-resistant UC.
- Endoscopic evaluation is standard, but blood biomarkers are needed.
Purpose of the Study:
- To investigate the correlation between neutrophil/monocyte-associated factors and therapeutic response to GMA in UC patients.
- To identify potential blood biomarkers for assessing GMA efficacy.
Main Methods:
- Prospective, 2-center study of 10 UC patients undergoing 10 GMA sessions.
- Peripheral blood samples collected before and after GMA.
- Analysis of neutrophil/monocyte-associated factors, including proteases like MMP-9.
Main Results:
- 60% of patients achieved remission after 10 GMA sessions.
- Matrix metalloproteinase-9 (MMP-9) levels showed a positive correlation with changes in clinical activity.
- Decreased circulating MMP-9 levels were observed in patients responding to GMA.
Conclusions:
- Decreased circulating MMP-9 levels may predict clinical response to GMA in UC patients.
- MMP-9 could serve as a novel, cost-effective biomarker for GMA efficacy.
- MMP-9 offers a potential substitute for traditional clinical assessment in UC.
More Related Videos
08:58Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
11:55Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease II: Ulcerative Colitis
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...