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Related Experiment Video

Updated: Apr 25, 2026

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
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Published on: May 23, 2025

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Intracortical microstructure profiling: A cross-modal method for indexing cortical lamination.

Casey Paquola1,2, Jessica Royer3,4, Thanos Tsigaras1,2

  • 1Institute for Neuroscience and Medicine (INM-7), Forschungszentrum Juelich, Juelich, Germany.

Imaging Neuroscience (Cambridge, Mass.)
|April 24, 2026
PubMed
Summary
This summary is machine-generated.

Intracortical microstructure profiling offers a robust method to analyze human brain layers using MRI. This technique, packaged in the CortPro toolbox, ensures reliable and reproducible results for studying brain organization.

Keywords:
cytoarchitecturein vivo histologymyeloarchitectureopen-source pipelinequantitative MRIsurface-based analysis

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Area of Science:

  • Neuroimaging
  • Human Brain Anatomy
  • Computational Neuroscience

Background:

  • Intracortical microstructure profiling is a scalable method for studying human cortical laminar organization.
  • It builds on histological analysis, using surface-based sampling to map tissue properties across cortical depths.
  • Existing methods require standardization for broader application.

Purpose of the Study:

  • To outline a standardized workflow for intracortical microstructural profiling.
  • To introduce the open-source toolbox "CortPro" for this analysis.
  • To evaluate central moments as descriptors of profile shape and assess their utility.

Main Methods:

  • Developed a standardized workflow for intracortical microstructural profiling.
  • Packaged the workflow into the open-source toolbox "CortPro".
  • Utilized central moments to quantify profile shape and assess in-vivo MRI's ability to capture laminar differentiation, test-retest reliability, and cross-site replicability.

Main Results:

  • Intracortical profiles demonstrate remarkable robustness.
  • The method effectively mitigates bias-field limitations inherent in non-quantitative MRI.
  • Quantified the reliability and replicability of microstructural profiles across sites and studies.

Conclusions:

  • Intracortical microstructure profiling is a reliable and reproducible method for analyzing cortical organization.
  • The CortPro toolbox provides a standardized approach for in-vivo and post-mortem datasets.
  • This technique facilitates the link between microstructural neuroanatomy and systems-level brain organization in various conditions.