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Transparency of medical artificial intelligence systems
Chanwoo Kim1, Soham U Gadgil1, Su-In Lee1
1Paul G. Allen School of Computer Science & Engineering, University of Washington, Seattle, WA, USA.
Nature Reviews Bioengineering
|April 24, 2026
Summary
Transparency in medical artificial intelligence (AI) is crucial for trust and safety. This review explores challenges and solutions for explainable AI in healthcare, promoting ethical development and clinical integration.
Area of Science:
- Medical Artificial Intelligence
- Healthcare Technology
- Clinical Decision Support Systems
Background:
- Artificial intelligence (AI) systems are increasingly integrated into healthcare, offering potential for improved diagnostics and treatment recommendations.
- The
- black box
- nature of many medical AI systems hinders trust and verification among patients, providers, and regulators.
- Transparency is essential for understanding AI design, operation, and outcomes in clinical settings.
Purpose of the Study:
- To examine the current state of transparency in medical AI systems.
- To identify challenges and risks associated with opaque AI systems in healthcare.
- To explore techniques promoting explainability and discuss regulatory frameworks for trustworthy AI.
Main Methods:
- Review of current literature on transparency and explainability in medical AI.
- Analysis of challenges in the AI machine learning pipeline, from data to deployment.
- Exploration of techniques for promoting explainability and continual monitoring.
Main Results:
- Many medical AI systems currently function as "black boxes," posing challenges for interpretation and trust.
- Various techniques can enhance explainability across the AI pipeline, from training data to model deployment.
- Overcoming barriers to integrating transparency tools and establishing clear regulatory frameworks are key.
Conclusions:
- Ensuring transparency in medical AI is vital for building trust and enabling ethical clinical integration.
- Explainable AI techniques and robust regulatory oversight are necessary for reliable and responsible AI healthcare solutions.
- Continued research and collaboration are needed to address challenges and advance trustworthy AI in medicine.
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