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Two Molecularly Defined Neuronal Types in the Mammillary Body Govern Different Temporal Periods during Working Memory
Yiqing Guo1,2,3, Lanfang Li1,2,4, Zhenye Hou1,2
1School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Research (Washington, D.C.)
|April 24, 2026
Summary
Neurotensin (Nts) and nitric oxide synthase 1 (Nos1) neurons in the mammillary body (MB) form distinct circuits. These circuits, regulated by Grik4, play crucial roles in working memory maintenance.
Area of Science:
- Neuroscience
- Molecular Biology
- Cognitive Science
Background:
- The mammillary body (MB) is recognized for its role in memory and its involvement in the Papez circuit.
- However, the detailed molecular and cellular organization of the MB remains poorly understood.
Purpose of the Study:
- To investigate the molecular and cellular underpinnings of distinct neuronal populations within the MB.
- To elucidate the circuit architecture and functional roles of neurotensin (Nts)-expressing and nitric oxide synthase 1 (Nos1)-expressing neurons in working memory.
Main Methods:
- Electrophysiological recordings to characterize neuronal properties.
- Circuit tracing to map inputs and outputs of Nts and Nos1 neurons.
- Behavioral tasks to assess working memory function.
Main Results:
- Identified Grik4 as a key determinant of distinct electrophysiological properties in Nts and Nos1 neurons.
- Demonstrated that Nts and Nos1 neurons receive convergent excitatory inputs from the ventral subiculum.
- Showed divergent projections to the anteroventral thalamus (AV) and dissociable roles in working memory maintenance with temporal differences.
Conclusions:
- Molecularly distinct Nts and Nos1 neurons form parallel circuits with specific roles in working memory.
- Established a link between molecular identity, circuit organization, and cognitive function within the MB.
- Revealed a cross-scale organizational principle (molecule, cell, circuit, function) in the MB.
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