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Congenital coralliform cataract is the predominant consequence of a recurrent mutation in the CRYGD gene.

Orphanet journal of rare diseases·2023
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Related Experiment Video

Updated: Apr 25, 2026

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Comparisons of Intraocular Lens Calculation Formulas for Eyes With Astigmatism: Systemic Review and Network

Zhi Chen1, Meng Li1, Zhi-Yong Tian1

  • 1Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China, ccmu.edu.cn.

Journal of Ophthalmology
|April 24, 2026
PubMed
Summary

The EVO MPCA formula demonstrated superior accuracy among 19 toric intraocular lens (IOL) power calculation formulas. This finding aids in optimizing refractive outcomes for patients undergoing cataract surgery.

Keywords:
astigmatismcataractintraocular lens power calculationnetwork meta-analysis

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Clinical Optics

Background:

  • Accurate intraocular lens (IOL) power calculation is crucial for successful cataract surgery.
  • Toric IOLs correct astigmatism, requiring precise power calculation to achieve desired refractive outcomes.
  • Various formulas exist for toric IOL power calculation, necessitating comparative analysis of their accuracy.

Purpose of the Study:

  • To compare the predictive accuracy of 19 different formulas for calculating toric intraocular lens (IOL) power.
  • To identify the most accurate formula for toric IOL power calculation in clinical practice.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, EBSCO, Web of Science, Cochrane Library) for studies from 2015-2025.
  • A meta-analysis synthesized prediction error (PE) data within ±0.50 and ±1.00 diopters (D).
  • Continuous vector analysis assessed directional bias in refractive outcomes.

Main Results:

  • Nine retrospective studies involving 1959 eyes were analyzed.
  • The EVO MPCA formula ranked highest for PE within ±0.5D (86.9%) and ±1.0D (83.7%).
  • Other top-performing formulas included Kane and Hoffer QST for PE within ±0.5D, and Haigis for PE within ±1.0D.

Conclusions:

  • The EVO MPCA formula demonstrated the best performance among the evaluated 19 toric IOL power calculation formulas.
  • This finding suggests EVO MPCA may lead to improved refractive predictability in toric IOL implantation.
  • Further research could explore real-world outcomes and formula performance across diverse patient populations.