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Updated: Apr 25, 2026
4D Multimodality Imaging of Citrobacter rodentium Infections in Mice
Published on: August 13, 2013
Characterization of NDM-4-Producing Citrobacter amalonaticus Isolates from China
Rong Yan1, Xiang Lian2, Hao Xu3
1Center for General Practice Medicine, Department of Infectious Diseases, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, People's Republic of China.
Objective:
The aim of this study was to investigate the genomic features of carbapenem-resistant Citrobacter spp. carrying blaNDM-4 on a novel IncFII-116 plasmid.
Methods:
Carbapenem-resistant Citrobacter spp. isolates were collected from diarrheal inpatients. Antibiotic susceptibility testing was routinely performed. Whole-genome sequencing and bioinformatic analyses were conducted on the isolates with blaNDM-4 gene.
Results:
Whole- genome sequencing was performed on the two C. amalonaticus isolates carrying bla NDM-4. Whole-genome analysis revealed that pL5091_blaNDM-4 and pL5094_blaNDM-4 belong to a new type of plasmid (IncFII-116) with lengths of 87124 bp and 87952 bp in two C. amalonaticus, respectively. Moreover, blaNDM-4 was encoded in the trpF-ble-bla NDM-4-IS15 cassette array.
Conclusion:
We identified a novel IncFII-116 plasmid carrying blaNDM-4 in C. amalonaticus for the first time, raising concerns about the emergence of carbapenem-resistant Citrobacter spp.
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