Related Experiment Video

Updated: May 4, 2026

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness
12:21

A Mouse Model for the Transition of Streptococcus pneumoniae from Colonizer to Pathogen upon Viral Co-Infection Recapitulates Age-Exacerbated Illness

Published on: September 28, 2022

3.9K

Post-COVID-19 Dynamics of Pediatric Respiratory Viruses in Wuhan: Epidemiology, Co-Infection Patterns, and Clinical

Jun'e Ma1, Ting Tian1, Xuewei Ren1

  • 1Department of Clinical Laboratory, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 40070, People's Republic of China.

Infection and Drug Resistance
|April 24, 2026
PubMed

Insights

Respiratory viruses are common in children post-COVID-19. Respiratory syncytial virus (RSV) co-infections present unique clinical signs compared to single RSV infections, impacting patient management.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Public health

Background:

  • The COVID-19 pandemic has altered the landscape of respiratory virus circulation.
  • Understanding post-pandemic viral prevalence in children is crucial for public health strategies.

Purpose of the Study:

  • To investigate the spectrum of respiratory viruses in children with respiratory symptoms in Wuhan after the COVID-19 pandemic.
  • To analyze the clinical characteristics of viral co-infections in this pediatric population.

Main Methods:

  • Retrospective analysis of 40,846 pharyngeal swabs from children with respiratory tract infections (January 2023 - August 2024).
  • Testing for nucleic acids of six common respiratory viruses.
  • Clinical data review for virus-positive cases, focusing on co-infections.

Main Results:

  • Overall virus positivity rate was 54.55%, with Adenovirus, Influenza A, and RSV being most prevalent.
  • Respiratory Syncytial Virus (RSV) and Influenza B (FluB) had the highest co-infection rate (2.03%).
  • RSV co-infections showed distinct clinical profiles (e.g., fever, elevated inflammatory markers) compared to single RSV infections.

Conclusions:

  • Respiratory viruses remain prevalent in symptomatic children in Wuhan, with specific seasonal and age-related patterns.
  • Viral co-infections, particularly involving RSV, are common and associated with altered clinical presentations.
  • Recognizing co-infection status is vital for effective clinical management of pediatric respiratory illnesses.
Abstract

Keywords:
COVID-19Co-infectionclinical severityepidemiologyrespiratory virus infection

More Related Videos

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

2.4K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

2.0K

Related Concept Videos

COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:
4.7K
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
1.4K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
4.2K
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
87
Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations01:19

Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations

Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet...
30