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Updated: Apr 25, 2026

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KDM2B-PP1 Promotes Remyelination and Functional Recovery After Facial Nerve Injury.

Huiyue Xu1, Haoqing Yang1, Yangyang Cao1

  • 1Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.

Journal of Oral Rehabilitation
|April 24, 2026
PubMed
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A novel peptide, KDM2B-PP1, enhances peripheral nerve repair by promoting Schwann cell remyelination and functional recovery after injury. This epigenetic modulator offers a promising therapeutic strategy for peripheral nerve injuries.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Epigenetics

Background:

  • Peripheral nerve injury (PNI) leads to lasting sensory and motor deficits due to poor regeneration and remyelination.
  • Schwann cells (SCs) are crucial for nerve repair, but their shift from a repair to a myelinating state is critical for recovery.

Purpose of the Study:

  • To investigate if KDM2B-PP1, a peptide targeting the KDM2B-EZH2 interaction, can improve SC redifferentiation, remyelination, and functional recovery post-PNI.

Main Methods:

  • In vitro: Rat SCs treated with KDM2B-PP1 to assess myelin gene/protein expression, proliferation, apoptosis, and migration.
  • In vivo: Rats with facial nerve transection received local KDM2B-PP1 to evaluate remyelination, nerve structure, and functional recovery.

Main Results:

Keywords:
Schwann cellbioactive peptidesepigenetic modulationmyelinationperipheral nerve regeneration

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  • KDM2B-PP1 disrupted KDM2B-EZH2 interaction, relieving repression of myelin genes and increasing myelin-associated transcripts/proteins (e.g., Olig1) in SCs.
  • In vivo, KDM2B-PP1 enhanced myelin sheath formation, improved nerve architecture, and promoted functional recovery post-injury.
  • KDM2B-PP1 did not significantly impact SC proliferation, apoptosis, or migration.

Conclusions:

  • KDM2B-PP1 acts as an epigenetic modulator, selectively promoting SC-mediated remyelination and functional recovery after PNI.
  • This study offers insights into epigenetic regulation of peripheral nerve regeneration.
  • KDM2B-PP1 shows potential as a therapeutic agent for PNI.