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Genetic Screens

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Related Experiment Video

Updated: Apr 25, 2026

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping

High-throughput DNA Extraction and Genotyping of 3dpf Zebrafish Larvae by Fin Clipping

Published on: June 29, 2018

A zebrafish module for genetic problem-solving.

Michael J Parsons¹, Star W Lee¹

¹Department of Developmental and Cell Biology, University of California, Irvine, California, USA.

Journal of Microbiology & Biology Education

|April 24, 2026

Summary

This summary is machine-generated.

This problem-based laboratory module improves undergraduate Mendelian genetics education by integrating experimental design with genetic crosses. Students effectively applied genetic concepts and improved their hypothesis formulation skills.

Keywords:

Mendelian inheritance experimental design problem-based learning zebrafish model system

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Last Updated: Apr 25, 2026

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Area of Science:

Genetics
Educational Research
Developmental Biology

Background:

Mendelian genetics instruction often challenges students in connecting fundamental principles to experimental design.
Undergraduate biology courses require effective pedagogical approaches to teach complex genetic concepts.

Purpose of the Study:

To develop and evaluate a problem-based laboratory module for teaching Mendelian genetics and experimental design.
To enhance students' ability to formulate hypotheses and design genetic crosses.

Main Methods:

A 3-week laboratory module was implemented for ~180 undergraduates using zebrafish and pigmentation mutants.
Students engaged in phenotypic discrimination, data collection, hypothesis formulation, chi-square analysis, and designing test crosses.

Main Results:

The module guided students from observation to genetic inference over two gene systems.
Students practiced formulating hypotheses and designing experiments, with ~72% reporting improved application of genetic concepts.

Conclusions:

The problem-based module effectively integrates Mendelian inheritance, statistical analysis, and hypothesis-driven experimental design.
This approach enhances student learning and practical application of genetic principles in a laboratory setting.