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Updated: Apr 25, 2026
Near Infrared Photoimmunotherapy for Mouse Models of Pleural Dissemination
Published on: February 9, 2021
Efficient Strategy for Diagnosis-Treatment-Monitoring Integrated Photodynamic Therapy by a Near-Infrared
Lingling Xu1, Yanzhe Zhu2, Yao Wang1
1School of Chemistry and Chemical Engineering & Institutes of Physical Science and Information Technology, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials & Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Anhui University, Hefei 230601, P. R. China.
A new probe, CMN, enables integrated cancer diagnosis, treatment, and monitoring via photodynamic therapy (PDT). This multifunctional fluorescent probe enhances PDT precision and allows real-time visualization of therapeutic effects.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Research
Background:
- Photodynamic therapy (PDT) offers controllable cancer treatment with low toxicity.
- Clinical PDT is limited by poor tumor specificity of conventional photosensitizers (PSs).
Purpose of the Study:
- To develop a novel near-infrared multifunctional fluorescent probe (CMN) for integrated cancer diagnosis, treatment, and monitoring.
- To overcome the limitations of conventional PSs by enhancing tumor specificity and enabling real-time treatment visualization.
Main Methods:
- Development of a multifunctional fluorescent probe (CMN) targeting cell membranes.
- Utilizing viscosity response for tumor specificity and differentiation of normal from cancer cells.
- Employing white light irradiation to activate CMN for reactive oxygen species (ROS) generation and tumor cell death.
- Real-time fluorescence imaging to visualize cell membrane damage and monitor therapeutic effects.
Main Results:
- CMN demonstrated tumor-specific imaging in mouse models.
- The probe enabled real-time visualization of PDT efficacy through in situ tumor imaging.
- CMN successfully generated ROS upon irradiation, inducing cancer cell death.
- Dynamic fluorescence imaging confirmed real-time visualization of cell membrane damage during PDT.
Conclusions:
- The developed probe CMN integrates diagnosis, treatment, and monitoring for enhanced PDT precision.
- CMN facilitates real-time visualization of PDT, offering significant potential for improved cancer therapy.
- This multifunctional probe overcomes limitations of conventional photosensitizers, paving the way for advanced cancer treatment strategies.
