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Elevated Body Mass Index Associates With Early Postoperative Recurrence in Pediatric Chronic Rhinosinusitis With
Yu Chen1, Ru Gao1, Tiansheng Wang1
1Department of Otolaryngology-Head and Neck Surgery, The Third Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Insights
Elevated body mass index (BMI) predicts recurrence in pediatric chronic rhinosinusitis with nasal polyps (CRSwNP). Postoperative weight gain further increases this risk, suggesting BMI is a key marker for monitoring CRSwNP patients.
Area of Science:
- Otolaryngology
- Pediatric Inflammatory Diseases
- Biomarker Discovery
Background:
- Pediatric chronic rhinosinusitis with nasal polyps (CRSwNP) is a challenging condition with frequent recurrence.
- Current biomarkers for predicting CRSwNP recurrence are limited.
- Identifying early predictive markers is crucial for effective patient management.
Purpose of the Study:
- To identify potential biomarkers for predicting early postoperative recurrence in pediatric CRSwNP patients.
- To investigate the association between clinical variables and CRSwNP recurrence.
- To establish BMI as a predictive marker for CRSwNP outcomes.
Main Methods:
- Retrospective study of 205 pediatric CRSwNP patients with 1-year follow-up.
- Collection of clinical variables and disease severity scores.
- Application of logistic regression, Kaplan-Meier analysis, and Cox models to identify risk factors.
Main Results:
- 114 patients (55.6%) experienced recurrence within 1 year.
- Higher BMI and allergic rhinitis (AR) were identified as independent predictors of recurrence.
- Elevated BMI correlated with shorter relapse-free survival; overweight/obese patients had significantly higher recurrence risk.
Conclusions:
- Elevated BMI is an independent risk factor for early postoperative recurrence in pediatric CRSwNP.
- Recurrence risk increases with higher BMI levels.
- BMI serves as a practical marker for postoperative risk stratification in pediatric CRSwNP.
Abstract:
BackgroundPediatric chronic rhinosinusitis with nasal polyps (CRSwNP) is a refractory inflammatory condition characterized by a high recurrence rate, yet reliable predictive biomarkers remain scarce. This study aimed to identify potential markers for early predicting postoperative recurrence in pediatric CRSwNP patients.MethodsA total of 205 pediatric patients with CRSwNP were retrospectively enrolled and followed postoperatively. Clinical variables and disease severity scores were collected. Logistic regression, Kaplan-Meier analysis, and Cox models were applied to identify risk factors associated with postoperative recurrence.ResultsAfter 1 year of follow-up, 114 patients experienced postoperative recurrence, whereas 91 remained recurrence-free. Patients with recurrence exhibited higher body mass index (BMI) and a greater prevalence of allergic rhinitis (AR). Multivariate analyses identified BMI and AR as independent predictors of early recurrence. Kaplan-Meier analysis demonstrated that elevated BMI was associated with shorter relapse-free survival, and stratified analyses confirmed a significantly increased recurrence risk among overweight and obese patients compared with those of normal weight, independent of potential confounders. Notably, among patients with normal baseline BMI, those who became obese within 1 year after surgery had a significantly higher recurrence rate, and postoperative BMI increased significantly only in patients who experienced recurrence.ConclusionElevated BMI was an independent risk factor for early postoperative recurrence in pediatric CRSwNP, with risk increasing alongside BMI levels. Postoperative weight gain further heightened recurrence risk, suggesting BMI as a practical marker for postoperative risk stratification.
