The efficacy of transcutaneous auricular Vagus nerve stimulation in non-specific chronic neck pain: A pilot study

BackgroundVagus nerve stimulation is primarily used for treating neuropsychiatric disorders, reducing inflammation, and controlling muscle tone. Nonspecific chronic neck pain is a prevalent musculoskeletal condition characterized by persistent neck pain without an identifiable structural pathology and is often associated with functional limitations, sleep disturbances, and reduced quality of life.ObjectiveThis pilot study evaluates the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) as a non-invasive treatment for nonspecific chronic neck pain.MethodsThirty-six participants were randomly assigned to a taVNS group or a conventional treatment group. Pain intensity, muscle strength and range of motion of the neck were primary outcomes, while neck disability and sleep quality were secondary outcomes. All measures were assessed at baseline and after 15 treatment sessions. Statistical analyses included mixed-methods ANOVA, Student's t-test, and Mann-Whitney U test.ResultstaVNS significantly reduced neck pain and improved extensor muscle strength, cervical range of motion, and sleep quality compared to baseline (p < 0.05). Compared with conventional treatment, the taVNS group showed greater improvements in extensor muscle strength and neck disability (p < 0.05), while other outcomes were similar between groups.ConclusiontaVNS appears to be a safe intervention with short-term effects comparable to conventional treatments in non-specific chronic neck pain. Although greater improvements were observed in muscle strength and neck disability, overall superiority was not demonstrated. Given the short duration and small sample size, the results cannot be generalized.Clinical Trials NumberNCT05527366.