Predictive Factors for Clinical Improvement Following a Manual Therapy-Based Program in Patients with Neck Pain: A
Emmanouil Kapernaros1, Maria Moutzouri1,2, Georgios Krekoukias1,2
1Master's Degree Program "New Methods in Physiotherapy", Physiotherapy Department, School of Health & Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece.
Reports (MDPI)
|April 24, 2026
Summary
Higher body mass (BM) and lower Minnesota Satisfaction Questionnaire (MSQ) scores predict short-term improvement in neck pain patients undergoing manual therapy. These factors aid in tailoring physiotherapy programs for better outcomes.
Area of Science:
- Orthopedics
- Rehabilitation Medicine
- Clinical Epidemiology
Background:
- Neck pain (NP) is a common condition impacting quality of life.
- Manual therapy (MT)-based physiotherapy is a frequent treatment approach for NP.
- Identifying predictors of treatment success can optimize patient care.
Purpose of the Study:
- To derive and validate a clinical prediction rule (CPR) for short-term improvement in NP patients.
- To identify baseline factors associated with positive outcomes in MT programs.
- To inform personalized rehabilitation strategies for neck pain.
Main Methods:
- Prospective cohort study of 71 NP patients (18-65 years) receiving 3 weeks of MT.
- Baseline assessments included pain, disability, body mass, physical activity, anxiety, depression, and satisfaction.
- Logistic regression and ROC analysis were used to develop the predictive model.
Main Results:
- 78.9% of patients showed moderate to complete improvement.
- Higher body mass (BM ≥ 76.5 kg) and lower Minnesota Satisfaction Questionnaire (MSQ score ≤ 42.5) predicted improvement.
- The combined predictors yielded a 96.43% probability of clinical improvement (LR+ = 7.58).
Conclusions:
- Higher body mass and lower MSQ scores are associated with better short-term outcomes in NP patients treated with MT.
- Integrating physical and psychosocial factors is crucial for effective NP rehabilitation.
- External validation of the derived CPR is necessary before clinical use.


