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Proteostasis, Assisted Reproductive Technologies, and Neurodevelopmental Differences: An Integrative Perspective.

Alberto Fucarino1, Yousef Mohamadi2, Francesco Cappello3

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Summary
This summary is machine-generated.

Proteostasis, the regulation of protein health, is vital for reproduction and development. Disrupted proteostasis links infertility and assisted reproductive technologies [ARTs] to potential neurodevelopmental differences [NDDs].

Keywords:
assisted reproductive technologies [ART]molecular chaperonesneurodevelopmental differences [NDD]proteostasis

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Area of Science:

  • Cellular Biology
  • Reproductive Science
  • Developmental Neuroscience

Background:

  • Proteostasis, the regulation of protein synthesis, folding, trafficking, and degradation, is critical for cellular integrity and development.
  • Efficient proteostasis is essential for reproductive success, including gamete quality, fertilization, embryonic development, and neurodevelopment.
  • Impaired proteostasis is increasingly linked to infertility and potential vulnerabilities associated with assisted reproductive technologies [ARTs].

Purpose of the Study:

  • To provide an integrative perspective on the role of disrupted proteostasis in infertility, ART procedures, and neurodevelopmental differences [NDDs].
  • To review evidence linking proteostasis failure to male and female infertility, focusing on molecular chaperones like heat shock protein 60 [Hsp60].
  • To highlight the impact of ART on epigenetic reprogramming and proteostasis during early embryogenesis, affecting neurodevelopmental outcomes.

Main Methods:

  • Review of epidemiological and molecular findings on proteostasis failure in infertility.
  • Emphasis on the role of molecular chaperones, particularly heat shock protein 60 [Hsp60].
  • Discussion of proteoforms, proteome complexity, and potential biomarkers for ART optimization.

Main Results:

  • Proteostasis failure is implicated in both male and female infertility.
  • Heat shock protein 60 [Hsp60] is a key mediator of mitochondrial function, protein quality control, and reproductive competence.
  • ART procedures may disrupt proteostasis and epigenetic stability, influencing neurodevelopmental outcomes.
  • Proteomic and chaperone-based biomarkers show potential for improving ART strategies and risk assessment.

Conclusions:

  • Proteostasis is a fundamental mechanism linking reproductive biology, ART outcomes, and long-term neurodevelopment.
  • Disruptions in proteostasis during ART may contribute to neurodevelopmental differences.
  • Further translational research is needed to leverage proteomic and chaperone insights for optimizing ART and assessing risks.