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Introducing the J-CONNECT database: a real-world oncology resource for Japan.

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The J-CONNECT database offers valuable real-world oncology data from Japanese electronic medical records. This multi-institutional resource supports cancer research, post-marketing surveillance, and public health policy in Japan.

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Area of Science:

  • Oncology
  • Real-World Data (RWD)
  • Real-World Evidence (RWE)

Background:

  • Randomized controlled trials in oncology often exclude diverse patient populations.
  • Real-world data (RWD) and real-world evidence (RWE) are crucial for comprehensive oncology research.
  • The J-CONNECT Consortium was established to create a high-quality RWD source in Japan.

Purpose of the Study:

  • To establish a multi-institutional database of chemotherapy-treated solid cancer patients in Japan.
  • To leverage electronic medical records (EMRs) for robust oncology data collection.
  • To provide a valuable resource for cancer research, post-marketing surveillance, and policy development.

Main Methods:

  • Data collection from 12 Ministry of Health, Labour and Welfare-designated cancer care hospitals, with planned expansion.
  • Linking hospital cancer registry data with EMRs to capture demographics, staging, treatments, and biomarkers.
  • Evaluation of data coverage and distributional characteristics against national cancer registry data.

Main Results:

  • The J-CONNECT database includes 51,497 patients diagnosed after 2018.
  • Major cancer types represented include breast, lung, prostate, colorectal, pancreas, stomach, esophagus, and liver.
  • Sex distributions align with national data, with some age-related variability observed.

Conclusions:

  • J-CONNECT is a robust oncology database with available clinical and biomarker data, suitable for various research applications.
  • The database's coverage, distributional characteristics, and regulatory acceptance underscore its value for research, PMS, and policy.
  • Future expansion and data integration will further enhance its utility for broader collaboration and public health initiatives.