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Staying IgD positive in a challenging environment
1Department of Biochemistry & Molecular Biology, Monash University, Clayton, Australia.
The Journal of Experimental Medicine
|April 24, 2026
Abstract:
The nasopharyngeal tissues provide a frontline defense against airborne exposure to viruses, bacteria, and allergens. In this issue of JEM, Tachó-Piñot et al. (https://doi.org/10.1084/jem.20251752) show that mutated IgD+ B cell subsets populate epithelial areas of nasopharyngeal mucosa, ready to tackle a multitude of antigenic targets.
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