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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Apr 26, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Association between Open-Angle Glaucoma Progression and Cardiovascular Risk Predicted by a Deep Learning-Based Fundus

Jooyoung Yoon1, Jaewon Seo2, Dongjin Nam3

  • 1Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Republic of Korea; Department of Ophthalmology, Hanyang University Guri Hospital, Guri, Gyeonggi-do, Republic of Korea.

Ophthalmology. Glaucoma
|April 24, 2026
PubMed
Summary

The RetiCAC score, a novel deep learning tool analyzing retinal images, predicts glaucoma progression. This noninvasive marker of vascular health shows significant association with visual field decline, independent of intraocular pressure.

Keywords:
AtherosclerosisDeep learningGlaucomaRetinal imagingVascular health

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Area of Science:

  • Ophthalmology
  • Cardiology
  • Artificial Intelligence

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Systemic vascular health is increasingly recognized as a factor in glaucoma progression.
  • Noninvasive methods to assess systemic vascular burden are needed for risk stratification.

Purpose of the Study:

  • To investigate the association between the RetiCAC score, a deep learning-derived measure of systemic atherosclerotic burden from retinal photographs, and the progression of glaucomatous visual fields (VF).

Main Methods:

  • Retrospective cohort study of 192 eyes with open-angle glaucoma.
  • RetiCAC scores estimated using deep learning from fundus photographs.
  • Generalized estimating equations (GEE) and Kaplan-Meier analysis used to assess factors associated with VF progression.

Main Results:

  • Higher RetiCAC scores, elevated peak intraocular pressure (IOP), and longer follow-up duration were independently associated with VF progression.
  • Patients in the high-risk RetiCAC group had a significantly higher probability of VF progression.
  • An inflection point for accelerated VF deterioration was observed at a RetiCAC score of 51.1.

Conclusions:

  • The RetiCAC score is a significant, independent predictor of glaucoma progression.
  • This noninvasive marker of systemic vascular health may aid in predicting glaucoma progression.
  • RetiCAC may reflect vascular dysfunction contributing to the pathogenesis of glaucoma.