Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

1.9K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.9K
Human Genetics01:28

Human Genetics

2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

1.4K
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
1.4K
Pedigree Analysis01:35

Pedigree Analysis

78.7K
Overview
78.7K
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

30.1K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
30.1K
Sex-linked Disorders01:43

Sex-linked Disorders

93.7K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
93.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Therapeutic potentials of curcumin in prostate cancer: a comprehensive review of pathways and clinical prospects.

Prostate international·2026
Same author

Preconception dietary patterns in association with live birth and pregnancy loss: a couples-based approach.

Fertility and sterility·2026
Same author

Giant Retinal Hole and Retinal Detachment following Exercise Band Injury: A Case Report.

Case reports in ophthalmology·2026
Same author

Advances in Wearable Bioimaging.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Impact of HCV infection on male reproductive hormones; a systematic review and meta-analysis.

International journal of impotence research·2026
Same author

Clinical Reasoning: An 81-Year-Old Woman With Chronic Isolated Neck Extensor Weakness.

Neurology·2026

Related Experiment Video

Updated: Apr 26, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.2K

Epigenetic Signatures in Family Clusters: Links Between Male Fertility and Autism Risk.

Hojat Dehghanbanadaki1, Justin Chen2, Samantha L Thorogood1

  • 1Division of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT.

Urology
|April 24, 2026
PubMed
Summary

Paternal sperm DNA methylation changes are linked to autism spectrum disorder (ASD) risk in children. These epigenetic alterations may be passed down, influencing neurodevelopment and ASD susceptibility across generations.

More Related Videos

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.6K
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.7K

Related Experiment Videos

Last Updated: Apr 26, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.2K
Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

2.6K
Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice
09:13

Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

Published on: July 11, 2025

26.7K

Area of Science:

  • Neuroscience
  • Genetics
  • Epigenetics

Background:

  • Autism spectrum disorder (ASD) prevalence is rising globally.
  • Paternal factors, including sperm DNA methylation, are increasingly implicated in offspring neurodevelopmental risk.
  • Advanced paternal age is associated with germline genetic and epigenetic alterations.

Purpose of the Study:

  • To investigate distinct sperm methylation signatures in fathers of children with ASD.
  • To explore the link between paternal methylation patterns and autistic traits in fathers and their children.
  • To assess the potential for intergenerational epigenetic transmission of ASD susceptibility.

Main Methods:

  • Analysis of sperm DNA methylation patterns in fathers of children with ASD.
  • Identification of specific genes with altered methylation, including those involved in neural function.
  • Longitudinal assessment of paternal methylation patterns and autistic traits in offspring.

Main Results:

  • Distinct sperm methylation signatures were identified in fathers of children with ASD.
  • Alterations were observed in genes critical for neural signaling, transcription, and synaptic function (e.g., WWOX, SALL3, A2BP1/RBFOX1).
  • Paternal methylation patterns correlated with autistic traits in both fathers and their children.

Conclusions:

  • Paternal sperm DNA methylation alterations represent a potential mechanism contributing to ASD susceptibility.
  • Evidence supports the intergenerational epigenetic transmission of ASD risk factors via sperm.
  • Further research into paternal epigenetic contributions is crucial for understanding and potentially preventing ASD.