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Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Related Experiment Video

Updated: Apr 26, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Pragmatic medicine, n=1.

Piotr Szawarski^1,2, David Hillebrandt³

¹Anaesthesia and Intensive Care Medicine, Wexham Park Hospital, Slough, UK piotr.szawarski@gmail.com.

Emergency Medicine Journal : EMJ

|April 24, 2026

Summary

Evidence-based medicine has limitations. Clinicians should use judgment alongside evidence, as absence of evidence does not mean absence of benefit for patient care.

Keywords:

Clinical Decision-Making Patient-Centered Care

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Last Updated: Apr 26, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Published on: April 29, 2007

Area of Science:

Clinical practice and medical research methodology.

Background:

Practicing clinicians express concerns regarding limitations in evidence-based medicine (EBM).
Concerns stem from research methodology, objectives, and the diverse settings where medical care is delivered.

Purpose of the Study:

To address the limitations and imperfections of evidence-based medicine.
To argue that absence of evidence does not equate to evidence of absence of benefit.

Main Methods:

Conceptual analysis and argumentation regarding the application of EBM in clinical practice.
Discussion on the role of clinical judgment alongside research evidence.

Main Results:

Absence of evidence for an intervention does not prove its ineffectiveness.
Sufficient solutions, prioritizing patient preference and context, may be pragmatic rather than indicative of practitioner ignorance.
Over-reliance on evidence without clinical judgment can be inappropriate.

Conclusions:

Medicine must be pragmatic, acknowledging evidence gaps.
Clinical judgment is crucial for finding solutions for individual patients.
A balanced approach integrating evidence and clinical expertise is necessary for effective patient care.