Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

5.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.8K
RNA-seq03:21

RNA-seq

9.2K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.2K
Sanger Sequencing01:57

Sanger Sequencing

800.4K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
800.4K
Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

830
Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
830

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validating Sequence Analysis Typologies Using Parametric Bootstrap.

Sociological methodology·2021
Same journal

A life-course approach to the relationship between adverse childhood experiences and mental health in a longitudinal UK birth cohort (ALSPAC).

Longitudinal and life course studies : international journal·2026
Same journal

Collecting saliva samples for DNA genotyping in a large-scale cohort study of young adults in England.

Longitudinal and life course studies : international journal·2026
Same journal

Finding meaning across time and place.

Longitudinal and life course studies : international journal·2026
Same journal

Transitions to old age: a multidimensional poverty approach for Chile.

Longitudinal and life course studies : international journal·2026
Same journal

What siblings share: how family background shapes early childhood socio-emotional difficulties in the United Kingdom.

Longitudinal and life course studies : international journal·2026
Same journal

Katariina Salmela-Aro obituary: a pioneer in longitudinal research.

Longitudinal and life course studies : international journal·2026
See all related articles

Related Experiment Video

Updated: Apr 26, 2026

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

6.7K

Sequence analysis for large databases.

Matthias Studer1, Rojin Sadeghi2, Louis Tochon2

  • 1https://ror.org/01swzsf04University of Geneva, Switzerlandandhttps://ror.org/00rqy9422University of Queensland, Australia.

Longitudinal and Life Course Studies : International Journal
|April 24, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces efficient sequence analysis methods for large datasets, overcoming computational challenges. The new techniques, including fuzzy and representativeness clustering, are validated with simulations and a large-scale family trajectories study.

Keywords:
cluster analysiscluster validationdissimilaritylarge databaseslife coursessequence analysis

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

10.0K

Related Experiment Videos

Last Updated: Apr 26, 2026

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens
09:14

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens

Published on: June 28, 2018

6.7K
Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

16.2K
High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq
09:06

High-throughput Identification of Gene Regulatory Sequences Using Next-generation Sequencing of Circular Chromosome Conformation Capture 4C-seq

Published on: October 5, 2018

10.0K

Area of Science:

  • Computational statistics
  • Data mining
  • Sociology

Background:

  • Traditional sequence analysis methods struggle with large databases due to high computational costs.
  • Developing scalable typologies for sequence data is crucial for analyzing complex patterns.

Purpose of the Study:

  • To develop and review scalable methods for sequence analysis typologies in large databases.
  • To extend existing algorithms with fuzzy and representativeness clustering for enhanced sequence analysis.
  • To introduce novel methods for assessing clustering quality and algorithm convergence without full distance computations.

Main Methods:

  • The study discusses the CLARA algorithm and extends it with fuzzy and representativeness clustering techniques.
  • Simulation studies are used to assess the strengths of different approaches and provide practical guidelines.
  • Three methods for evaluating clustering quality are presented: bootstrapping, medoid-based approaches, and a novel clustering stability method.

Main Results:

  • The proposed methods offer efficient solutions for creating sequence analysis typologies in large datasets.
  • Clustering stability provides an innovative way to assess convergence and quality.
  • The methods are successfully illustrated using a large dataset of family trajectories in India.

Conclusions:

  • The developed methods significantly improve the feasibility of sequence analysis for very large databases.
  • The WeightedCluster R package makes these advanced sequence analysis techniques accessible to researchers.
  • The study provides practical guidelines and novel approaches for robust clustering of sequence data.