Synergistic Restoration of Scarred Vocal Folds Using 532 nm Laser and Fibroblast Growth Factor

This study aimed to evaluate the safety and feasibility of a combined regenerative approach using 532 nm laser glottoplasty followed by basic fibroblast growth factor (βFGF) injection therapy in patients with chronic vocal fold scarring.

Prospective clinical study.

Between September 2021 and August 2025, 23 patients diagnosed with type I (n = 13) or type II (n = 10) vocal fold scarring underwent 532 nm laser glottoplasty, followed by intracordal βFGF injection performed at 2 weeks after the laser procedure. All patients completed both subjective and objective voice assessments at baseline and during the follow-up period.

Most objective voice parameters demonstrated improvement after the combined treatment. Jitter and shimmer values showed statistically significant improvement at 6 and 12 months postoperatively (P < 0.05). Subjective voice measures significantly improved as early as 1 month after treatment, and these improvements were maintained throughout the 12-month follow-up period. No serious procedure-related complications were observed.

Sequential 532 nm laser glottoplasty followed by βFGF injection may represent an alternative treatment approach for improving voice quality in patients with chronic vocal fold scarring.