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Continuous Theta Burst Stimulation of the Posterior Medial Frontal Cortex to Experimentally Reduce Ideological Threat Responses
Published on: September 28, 2018
Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics
Elmira Khatamsaz1, Tudor M Ionescu1, Katja Keppler1
1Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.
Abstract:
Social interactions are critical for mental health and are frequently disrupted in neuropsychiatric disorders. Clinical data suggest a link between dysfunction of the default mode network (DMN) and social impairment. To advance our understanding of the neurobiological mechanisms underlying social dysfunction, we back-translate these clinical findings into a preclinical setup, demonstrating that impaired DMN connectivity - achieved through activation of Parvalbumin interneurons in the orbitofrontal cortex (OFC) reduces normal social behaviour.
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