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Stem Cell Therapy for Tissue Regeneration01:21

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Cell-engineered technologies for wound healing and tissue regeneration.

Malay Nayak1, Durba Banerjee1, Vangala Venugopal2

  • 1School of Biomedical Engineering, IIT (BHU), Varanasi, Uttar Pradesh, India.

Npj Biomedical Innovations
|April 24, 2026
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Summary

This review explores cell-engineered technologies for wound healing and tissue regeneration. It covers genetic modifications, cell delivery systems like hydrogels and 3D bioprinting, clinical applications, and future research directions.

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Wound healing and tissue regeneration remain significant clinical challenges.
  • Cell-based therapies offer promising solutions but require advanced engineering.
  • Diverse cell-engineered technologies are emerging for therapeutic applications.

Purpose of the Study:

  • To comprehensively review diverse cell-engineered technologies for wound healing and tissue regeneration.
  • To highlight various engineered techniques, genetic modifications, and delivery systems.
  • To evaluate clinical applicability and identify future research directions.

Main Methods:

  • Literature review of cell-engineered technologies for wound healing and tissue regeneration.
  • Analysis of genetic modification strategies to enhance cellular properties.
  • Exploration of cell delivery systems such as hydrogels and 3D bioprinting.
  • Evaluation of clinical translation and challenges.

Main Results:

  • Various cell types can be genetically modified to improve therapeutic efficacy.
  • Hydrogels and 3D bioprinting represent innovative approaches for cell delivery.
  • Significant progress has been made in translating these technologies towards clinical use.
  • Key challenges in scalability, regulation, and long-term efficacy persist.

Conclusions:

  • Cell-engineered technologies hold immense potential for advancing wound healing and tissue regeneration.
  • Optimizing genetic modifications and delivery systems is crucial for therapeutic success.
  • Addressing clinical and regulatory hurdles is essential for widespread adoption.