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Updated: Apr 26, 2026

Characterization of Intra-Cartilage Transport Properties of Cationic Peptide Carriers
Published on: August 10, 2020
Peptide-based targeted drug delivery strategies for osteoarthritis treatment
Bill Hakim1, Hengli Zhang1, Andrew Selvadoss2
1Departments of Bioengineering, Northeastern University, Boston, MA, USA.
Abstract:
Peptide-based strategies offer promising solutions to overcome the complex, multi-tissue barriers of osteoarthritis. Their tunability, specificity, and versatility enable targeted drug delivery to cartilage, synovium, and subchondral bone, while some therapeutic peptides provide intrinsic anti-inflammatory, regenerative, or analgesic effects. Advances in peptide design, stability engineering, and in silico screening, alongside emerging human joint-on-chip models, are accelerating the development of targeted, stable, multi-tissue OA therapies.
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